Learn about Activella (estradiol / norethindrone) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Estradiol and norethindrone is a combination medicine used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. This medicine is a combination of two hormones: an estrogen hormone (estradiol) and a progestin hormone (norethindrone). These hormones are absorbed through your skin into your body. When prescribing solely for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause, first consider the use of topical vaginal products. When prescribing solely for the prevention of postmenopausal osteoporosis, first consider the use of non-estrogen medications. Estradiol and norethindrone combination is used to treat moderate to severe symptoms of menopause (eg, feelings of warmth in the face, neck, and chest, sudden strong feelings of heat and sweating [hot flashes], and vaginal problems). This medicine is also used prevent osteoporosis after menopause. Overview: Norethindrone/ethinyl estradiol is a hormonal birth control pill that is used to prevent pregnancy. Common side effects include nausea, headache, and breast tenderness. Using estradiol and norethindrone can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estradiol and norethindrone should not be used to prevent heart disease, stroke, or dementia. ESTRADIOL; NORETHINDRONE (es tra DYE ole; nor eth IN drone) relieves the symptoms of menopause, such as hot flashes or vaginal dryness. It may also be used to prevent osteoporosis. In this comprehensive guide, we’ll delve into estradiol norethindrone, exploring what it is, how it works, its benefits, potential risks, and who might be an ideal candidate. Estradiol/norethindrone is used to relieve hot flashes, night sweats, and vaginal changes due to menopause, to prevent osteoporosis after menopause, or raise estrogen levels when the ovaries.