Estradiol and norethindrone combination is used to treat moderate to severe symptoms of menopause (eg, feelings of warmth in the face, neck, and chest, sudden strong feelings of heat and sweating [hot flashes], and vaginal problems). This medicine is also used prevent osteoporosis after menopause. General Guidance and Intended Use: This equivalency table is intended as a general clinical guide to assist healthcare providers in initiating or switching between various estrogen and progestogen formulations commonly used in menopause management. ESTRADIOL; NORETHINDRONE (es tra DYE ole; nor eth IN drone) relieves the symptoms of menopause, such as hot flashes or vaginal dryness. It may also be used to prevent osteoporosis. Estradiol and norethindrone is a combination medicine used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Prescribe estrogens with or without progestogens at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Estradiol/norethindrone acetate is a combination hormone replacement therapy used to relieve menopausal symptoms (hot flushes, vaginal dryness and atrophy, and bone loss). Overview: Norethindrone/ethinyl estradiol is a hormonal birth control pill that is used to prevent pregnancy. Common side effects include nausea, headache, and breast tenderness. Learn about Activella (estradiol / norethindrone) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Each tablet of Activella 0.5 mg/ 0.1 mg contains 0.5 mg of estradiol and 0.1 mg of norethindrone acetate. The tablets are white, round, biconvex, film-coated tablets debossed with “ALL” on the. Estradiol/Norethindrone is a combination hormone replacement therapy (HRT) used to treat menopause symptoms like hot flashes, night sweats, and vaginal dryness.